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[Ileal inflammatory fibroid polyp: case report].

C Y Chai1, M F Hou, T J Huang

  • 1Department of Pathology, Kaohsiung Medical College, Taiwan, Republic of China.

Gaoxiong Yi Xue Ke Xue Za Zhi = the Kaohsiung Journal of Medical Sciences
|October 1, 1992
PubMed
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Inflammatory fibroid polyps are rare gastrointestinal lesions. This case report details an ileal inflammatory fibroid polyp causing intussusception, supporting a fibroblastic origin.

Area of Science:

  • Gastroenterology and Pathology
  • Gastrointestinal Oncology

Background:

  • Inflammatory fibroid polyps (IFPs) are uncommon, benign neoplastic lesions of the gastrointestinal tract.
  • They most frequently occur in the stomach, followed by the small and large intestines.
  • The histogenesis and pathogenesis of IFPs remain largely uncertain.

Observation:

  • This case report presents an unusual instance of an IFP located in the ileum.
  • The ileal IFP led to a significant clinical complication: ileoileal intussusception.
  • Microscopic examination revealed a lesion composed of spindle-shaped or stellate cells.

Findings:

  • Immunohistochemical analysis showed strong vimentin positivity and focal S100 protein positivity.
  • Negative staining for epithelial membrane antigen, factor VIII R Ag, smooth muscle actin, and lysozyme was observed.

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  • These findings support the hypothesis that IFPs originate from fibroblastic cells.

    • Implications:

    • This case expands the known anatomical locations for IFPs.
    • Understanding the fibroblastic origin aids in accurate diagnosis and differentiation from other mesenchymal tumors.
    • Further research into IFP pathogenesis may reveal potential therapeutic targets.