Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomarkers in osteoarthritis.

Patrick Garnero1, Pierre D Delmas

  • 1INSERM Research Unit 403, Lyon, France. patrick.garnero@synarc.com

Current Opinion in Rheumatology
|September 10, 2003
PubMed
Summary

New biologic markers can help identify patients with osteoarthritis at risk for rapid joint destruction. Combining markers for cartilage turnover shows promise for predicting disease progression and monitoring new treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cartilage turnover, but not novel synovial collagen marker, is associated with joint damage progression in osteoarthritis patients.

Rheumatology (Oxford, England)·2025
Same author

Serum biochemical marker of synovial tissue turnover, C1M, predicts radiological progression in early rheumatoid arthritis.

RMD open·2025
Same author

Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism.

Clinical chemistry and laboratory medicine·2024
Same author

Whole-body vibration may not affect bone mineral density and bone turnover in persons with chronic spinal cord injury: A preliminary study.

The journal of spinal cord medicine·2023
Same author

Plasma Cartilage Acidic Protein 1 Measured by ELISA Is Associated With the Progression to Total Joint Replacement in Postmenopausal Women.

The Journal of rheumatology·2023
Same author

A new serum biochemical marker of synovium turnover predicts radiographic progression in patients with early arthritis.

Rheumatology (Oxford, England)·2023

Area of Science:

  • Biomarkers
  • Osteoarthritis Research
  • Rheumatology

Background:

  • Osteoarthritis (OA) involves progressive joint tissue destruction.
  • Current diagnostic methods lack sensitivity for monitoring OA progression.
  • Biologic markers offer potential for tracking dynamic changes in joint tissues.

Purpose of the Study:

  • To review the role of novel biologic markers in osteoarthritis.
  • To assess the utility of these markers in predicting disease progression.
  • To explore their application in monitoring treatment response.

Main Methods:

  • Review of prospective studies on tissue-specific biologic markers.
  • Analysis of markers for type II collagen synthesis and degradation.
  • Evaluation of marker combinations for predicting radiologic progression.

Main Results:

  • New markers for collagen synthesis/degradation and synovitis are available.
  • Certain marker levels correlate with rapid joint destruction in knee OA.
  • A combined marker index improved prediction of 1-year radiologic progression in OA.

Conclusions:

  • Combined biologic markers can identify osteoarthritis patients at high risk for joint destruction.
  • Biomarkers' responsiveness to treatment aids in developing structure-modifying OA therapies.
  • Markers are crucial for monitoring novel osteoarthritis treatments.

Related Experiment Videos