[Therapeutic progress in treatment of childhood lymphosarcoma (author's transl)]

In treating childhood lymphosarcoma, high-dose combination chemotherapy is most effective, when given as long-term therapy. The most important advances of the therapeutic regimen described here are not only obtaining complete remissions but to have them maintained; the side-effects of the intensive therapy are well to be kept under control. Besides, some of the drugs are effective against the severe complications, leucemic transformation and sacromatous meningiosis. The median time of complete remission in our own patients with head and neck primaries is already 63 weeks; in comparison, that of a former group of children was 11 weeks.