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No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia
Erik G Jönsson1, Rami Abou Jamra, Johannes Schumacher
1Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, SE-171 76 Stockholm, Sweden. erikj@ks.se
Objective:
Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia.
Methods:
Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant.
Results:
No significant allele or genotype differences were found.
Conclusions:
The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.