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Altered lymphocyte heat shock protein 70 expression in patients with HIV disease
Linda L Agnew1, Mark Kelly, Jonathan Howard
1School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale, NSW 2350, Australia.
Abstract:
Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 +/- 2.97 in HIV-positive individuals compared with 2.60 +/- 1.29 for HIV-negative controls (P= 0.001). Given clear roles for HSP in the cross-presentation of antigens, alpha-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.
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