Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is the tendon embryogenesis process resurrected during tendon healing?

John M Ingraham1, Randy M Hauck, H Paul Ehrlich

  • 1Penn State College of Medicine and Department of Surgery, Milton S. Hershey Medical Center, PA, USA.

Plastic and Reconstructive Surgery
|September 10, 2003
PubMed
Summary

Embryonic tendon development involves collagen fibril segments assembling on fibroblast surfaces. Tendon repair may mirror this embryonic process, requiring further study of fibroblast roles in collagen fiber regeneration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply: Which Characteristics of Applicants and Medical Schools Produce the Most Integrated Plastic Surgery Residents? An Analysis of the 2016-2022 Cohort.

Plastic and reconstructive surgery. Global open·2025
Same author

Which Characteristics of Applicants and Medical Schools Produce the Most Integrated Plastic Surgery Residents? An Analysis of the 2016-2022 Cohort.

Plastic and reconstructive surgery. Global open·2025
Same author

Surface wear of PyroCarbon implant in metacarpophalangeal joint arthroplasty without radiographic abnormality: A case report.

Hand surgery & rehabilitation·2024
Same author

Minimally Invasive Cubital Tunnel Release Utilizing Lighted Retractors: A Study of Residents Novel to this Technique Utilizing a Cadaveric Model.

Journal of surgical orthopaedic advances·2024
Same author

The Cost Does Not Outweigh the Benefit: Pathologic Evaluation of Wrist Ganglion Cysts Should Not Be Routine.

Hand (New York, N.Y.)·2023
Same author

Acute limb shortening or creation of an intentional deformity to aid in soft tissue closure for IIIB/IIIC open tibia fractures.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2021

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Orthopedics

Background:

  • Tendon development involves collagen fibril segment assembly.
  • Current models of tendon healing focus on tropocollagen polymerization.
  • The role of fibroblasts in embryonic tendon formation is established.

Purpose of the Study:

  • To review embryonic tendon development and collagen fibril formation.
  • To propose a link between embryonic tendon fibrillogenesis and tendon repair.
  • To highlight the need for studying fibroblast involvement in tendon healing.

Main Methods:

  • Literature review of embryonic tendon development.
  • Analysis of existing biochemical models of tendon healing.
  • Identification of research gaps in understanding tendon intrinsic repair.

Related Experiment Videos

Main Results:

  • Collagen fibril segments assemble on fibroblast surfaces during embryonic development.
  • The process of embryonic fibrillogenesis may inform understanding of repair.
  • Biochemical models of tendon healing may be incomplete.

Conclusions:

  • Tendon repair mechanisms may be related to embryonic development processes.
  • Fibroblast involvement in collagen fiber reassembly during healing requires further investigation.
  • Intrinsic regenerative repair in tendons necessitates studying direct fibroblast contributions.