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Updated: Aug 6, 2026
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Anti-angiogenesis in cancer therapy
1Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD, USA.
Seminars in Oncology Nursing
|September 10, 2003
Summary
This review explores tumor angiogenesis, a key process in cancer development. It identifies targets for anti-angiogenic cancer therapy and discusses agents currently in clinical trials.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Therapeutics
Background:
- Tumor angiogenesis is the process of new blood vessel formation that supports tumor growth and metastasis.
- Understanding tumor angiogenesis is crucial for developing effective cancer treatments.
- This process involves complex molecular signaling pathways that can be targeted therapeutically.
Purpose of the Study:
- To review the process of tumor angiogenesis.
- To identify potential molecular targets for anti-angiogenic cancer therapy.
- To highlight anti-angiogenic agents currently undergoing clinical evaluation.
Main Methods:
- Literature review of research articles, abstracts, review articles, and book chapters.
- Synthesis of information on tumor angiogenesis mechanisms.
- Analysis of data from ongoing clinical trials of anti-angiogenic agents.
Main Results:
- Tumor angiogenesis is a critical, multistep process essential for tumor survival and growth.
- Several molecular targets within the angiogenic pathway have been identified for therapeutic intervention.
- Various anti-angiogenic agents are in different phases of clinical trials, showing promise in cancer treatment.
Conclusions:
- Targeting tumor angiogenesis offers a viable strategy for antineoplastic therapy by disrupting tumor neovasculature.
- Ongoing clinical trials are evaluating the efficacy and application of novel anti-angiogenic agents.
- Oncology nurses require updated knowledge to effectively educate and care for patients receiving these targeted therapies.
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