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Published on: August 25, 2021
Molecular targets in cancer therapy
1Oncology Clinical Coordinator Program, Genentech BioOncology, South San Francisco, CA, USA.
Objectives:
To review selected pharmacologic agents that target key cellular processes along with their mechanisms of action and adverse events. Nursing implications including what patients and families need to know, administration issues, and management of common toxicities will be reviewed.
Data Sources:
Research articles, clinical trials, abstracts, and book chapters.
Conclusion:
Knowledge of complex biology and biochemistry regulating normal and abnormal cellular function obtained over the past 30 years is starting to be used clinically for new therapies to treat cancer. By targeting what makes cancer unique, these therapies are able to spare more healthy or normal cells than the standard treatments, such as radiation and chemotherapy. Several molecular targeting agents are now in use and even more are under study as cancer treatments.
Implications For Nursing Practice:
Oncology nurses must understand the principles underlying targeted treatments and their potential benefits to provide adequate patient education and care.
Insights
New cancer therapies target unique cellular processes, sparing healthy cells. Oncology nurses need to understand these molecular targeting agents for effective patient care and education.
Area of Science:
- Molecular biology and biochemistry
- Pharmacology
- Oncology
Background:
- Decades of research into cellular processes have led to novel cancer therapies.
- Targeted therapies offer a more precise approach compared to traditional treatments like chemotherapy and radiation.
Purpose of the Study:
- To review pharmacologic agents targeting key cellular processes in cancer.
- To discuss their mechanisms of action, adverse events, and nursing implications.
Main Methods:
- Review of research articles, clinical trials, abstracts, and book chapters.
Main Results:
- Several molecular targeting agents are currently in clinical use for cancer treatment.
- Numerous other targeted agents are under investigation.
Conclusions:
- Targeted therapies leverage an understanding of cancer's unique biology to minimize harm to healthy cells.
- Oncology nurses require comprehensive knowledge of targeted treatments to ensure optimal patient education and care.
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