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Published on: June 5, 2014
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia
R S Beroukhim1, T D Moon, E I Felner
1Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112-2699, USA.
Summary
Neonatal thyrotoxicosis from maternal Graves
Area of Science:
- Neonatology
- Endocrinology
- Pediatric Gastroenterology
Background:
- Graves' disease in pregnant individuals can cause neonatal thyrotoxicosis.
- Maternal thyroid-stimulating immunoglobulins cross the placenta, affecting fetal thyroid function.
Observation:
- A neonate presented with typical hyperthyroid symptoms.
- The infant also developed conjugated hyperbilirubinemia.
Findings:
- This case highlights conjugated hyperbilirubinemia as a potential, previously unreported complication of neonatal thyrotoxicosis.
- The infant's condition resolved with appropriate treatment.
Implications:
- Clinicians should consider conjugated hyperbilirubinemia in neonates with thyrotoxicosis.
- Further research is needed to understand the mechanism and prevalence of this association.
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