Related Experiment Video

Updated: Feb 10, 2026

Modeling Persistent Pseudomonas aeruginosa Infection in Wounded Zebrafish Larvae
06:04

Modeling Persistent Pseudomonas aeruginosa Infection in Wounded Zebrafish Larvae

Published on: June 13, 2025

709

Current and future perspectives for levofloxacin in severe Pseudomonas aeruginosa infections

F Marchetti1, P Viale

  • 1Antibacterials-Medical Department, GlaxoSmithKline S.p.a, Verona, Italy.

Journal of Chemotherapy (Florence, Italy)
|September 10, 2003
PubMed

Insights

Levofloxacin demonstrates significant in vitro activity against Pseudomonas aeruginosa. Clinical studies confirm its efficacy in treating infections caused by this bacterium, supporting its use in pseudomonal infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pseudomonas aeruginosa is an opportunistic pathogen frequently associated with severe infections.
  • The clinical utility of fluoroquinolones, including levofloxacin, against P. aeruginosa remains an important therapeutic consideration.

Purpose of the Study:

  • To evaluate the spectrum of clinical activity of levofloxacin against Pseudomonas aeruginosa.
  • To synthesize evidence on the efficacy of levofloxacin for P. aeruginosa infections.

Main Methods:

  • Review of major findings on levofloxacin's activity against P. aeruginosa, with a focus on Italian publications.
  • Analysis of in vitro susceptibility data from thousands of strains globally.
  • Examination of published clinical results documenting treatment outcomes.

Main Results:

  • Levofloxacin exhibits documented in vitro activity against a wide range of P. aeruginosa strains.
  • The pharmacodynamic profile of levofloxacin supports its use in treating infections caused by this pathogen.
  • Extrapolated clinical data confirm the effectiveness of levofloxacin in treating P. aeruginosa-sustained infections.

Conclusions:

  • Levofloxacin possesses a spectrum of activity that includes Pseudomonas aeruginosa.
  • The drug is effective for treating infections caused by P. aeruginosa.
  • Evidence supports the clinical use of levofloxacin for pseudomonal infections.

More Related Videos

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection06:56

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

Published on: February 20, 2020

9.1K
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.9K

Related Concept Videos

Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
377
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
838
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K
Electrical Current01:10

Electrical Current

Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
7.2K