Regulation of hepatic and peripheral glucose disposal

Precise regulation of hepatic and peripheral glucose uptake is essential to preserve glucose homeostasis. The liver extracts approximately 1/3 of an oral glucose load, skeletal muscle extracts approximately 1/3, and other tissues, particularly the central nervous system and the formed elements of the blood, take up the balance. The load of glucose reaching the liver, the insulin concentration, and the route of glucose delivery (the hepatic portal or a peripheral vein) are key determinants of the rate of net hepatic glucose uptake. Glucose uptake by muscle requires three steps: delivery of glucose from the blood to the muscle, transport of glucose across the muscle membrane, and phosphorylation of glucose, processes affected by glycaemia and insulinaemia. Exercise stimulates insulin-dependent and -independent muscle glucose uptake, as well as the liver's ability to take up glucose.