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Mast cells in allergy and beyond.

I Puxeddu1, A M Piliponsky, I Bachelet

  • 1Faculty of Medicine, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.

The International Journal of Biochemistry & Cell Biology
|September 10, 2003
PubMed
Summary

Mast cells (MC) are key immune cells involved in allergic reactions and beyond. This review explores their expanding roles in immunity, wound healing, and diseases.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells (MC) are granulated tissue-resident cells originating from bone marrow progenitors.
  • Their growth, differentiation, survival, and activation depend on stem cell factor (SCF) binding to the c-kit receptor.
  • MC release numerous inflammatory and immunoregulatory mediators upon activation via IgE-dependent or -independent pathways.

Purpose of the Study:

  • To review current advances in understanding the multifaceted roles of mast cells.
  • To highlight mast cell involvement beyond allergic reactions and parasite infections.

Main Methods:

  • This is a review article, synthesizing existing research.
  • It focuses on analyzing published data regarding mast cell functions.

Main Results:

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  • Mast cells are implicated in innate and acquired immunity.
  • Emerging evidence shows their importance in wound healing, fibrosis, tumor development, and autoimmune diseases.

Conclusions:

  • Mast cells are crucial immune regulators with diverse functions.
  • Their roles extend significantly beyond traditional associations with allergy and parasitic infections, impacting various physiological and pathological processes.