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[Factors for successful conversion of atrial fibrillation using intravenous injection of pilsicainide hydrochloride]

Kohei Matsushita1, Toshiyuki Ishikawa, Shinichi Sumita

  • 1Second Department of Internal Medicine, Yokohama City University School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama 236-0004.

Journal of Cardiology
|September 11, 2003
PubMed

Insights

Intravenous pilsicainide hydrochloride successfully converted atrial fibrillation in 27% of patients. Success was linked to shorter atrial fibrillation duration, smaller left atrium, and faster heart rates before treatment.

Area of Science:

  • Cardiology
  • Pharmacology
  • Electrophysiology

Context:

  • Atrial fibrillation (AF) is a common arrhythmia requiring effective treatment.
  • Pilsicainide hydrochloride is an antiarrhythmic drug with intravenous administration for AF.
  • Factors influencing successful AF conversion with intravenous pilsicainide hydrochloride remain unclear.

Purpose:

  • To investigate the efficacy of intravenous pilsicainide hydrochloride for symptomatic atrial fibrillation.
  • To identify factors associated with successful cardioversion of atrial fibrillation.

Summary:

  • A study of 26 patients with symptomatic atrial fibrillation treated with intravenous pilsicainide hydrochloride (1.0 mg/kg).
  • Successful conversion to sinus rhythm occurred in 7 patients (27%).
  • Key factors for successful conversion included shorter AF duration, smaller left atrial dimension, and higher pre-treatment heart rates.

Impact:

  • Pilsicainide hydrochloride demonstrates effectiveness in specific patient subgroups.
  • Identifies patient characteristics (short AF duration, small left atrium, rapid ventricular response) predictive of successful treatment.
  • Informs clinical decision-making for intravenous pilsicainide hydrochloride use in atrial fibrillation management.
Abstract

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