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Related Experiment Videos

Experimental paracoccidioidomycosis in dogs.

M A Ono1, M O Kishima, E N Itano

  • 1Universidade Estadual de Londrina, Departamento de Ciências Patológicas, Londrina, PR, Brazil.

Medical Mycology
|September 11, 2003
PubMed
Summary

Dogs can develop paracoccidioidomycosis after experimental infection with Paracoccidioides brasiliensis. This study highlights dogs as sensitive indicators for detecting this fungal pathogen in the environment.

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Area of Science:

  • Veterinary Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis.
  • The role of dogs in the epidemiology of paracoccidioidomycosis is not well understood.
  • Identifying susceptible animal models is crucial for understanding disease pathogenesis and transmission.

Purpose of the Study:

  • To experimentally infect puppies with Paracoccidioides brasiliensis to evaluate their susceptibility.
  • To determine the clinical, pathological, and microbiological outcomes of experimental paracoccidioidomycosis in dogs.
  • To assess the potential of dogs as sentinels for environmental Paracoccidioides brasiliensis contamination.

Main Methods:

  • Puppies were inoculated intravenously with Paracoccidioides brasiliensis.

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  • Histopathological analysis was performed on tissues from deceased and euthanized animals.
  • Cultures were obtained from organs to isolate the fungus.
  • Skin testing with gp43 antigen was used to assess immune response in survivors.

    • Main Results:

    • Two of four puppies died within one week post-inoculation, exhibiting granulomas in lungs, spleen, and liver.
    • Paracoccidioides brasiliensis was successfully isolated from the organs of deceased puppies.
    • Surviving dogs developed a strong skin test reaction to gp43 antigen.
    • No macroscopic or microscopic lesions or fungal cultures were found in surviving dogs at 1 and 5 months post-infection.

    Conclusions:

    • Dogs are susceptible to developing paracoccidioidomycosis following experimental infection.
    • The study supports the use of dogs as a sensitive indicator species for environmental Paracoccidioides brasiliensis.
    • Further research into canine paracoccidioidomycosis can elucidate disease dynamics and host-pathogen interactions.