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Mitral valve prolapse: two dimensional echocardiography reveals a high prevalence in three to twelve year old
Insights
Mitral valve prolapse (MVP) is common in children up to 12 years old, affecting 13.1% of those studied. Echocardiography is a superior diagnostic tool for MVP compared to mid-systolic murmurs.
Area of Science:
- Pediatric Cardiology
- Echocardiography
- Valvular Heart Disease
Background:
- Mitral valve prolapse (MVP) prevalence is thought to be age-related, potentially being more common in younger populations.
- Previous assumptions suggested asymptomatic MVP might be most frequent in very young children.
Purpose of the Study:
- To accurately determine the prevalence of mitral valve prolapse (MVP) in young children.
- To investigate the relationship between MVP and various demographic and clinical factors in pediatric populations.
Main Methods:
- Prospective survey of 213 healthy urban school children aged 3-12 years.
- Diagnosis of MVP using two-dimensional and M-mode echocardiography at parasternal long-axis views.
- Analysis of prevalence across different age groups and correlation with sex, birth weight, heart rate, and blood pressure.
Main Results:
- Overall MVP prevalence was 13.1% (28/213 children) and consistent across studied age groups (3-5.9, 6-8.9, and 9-12 years).
- MVP prevalence was independent of sex, birth weight, resting heart rate, and blood pressure.
- A mid-systolic murmur was present in 50.6% of children but correlated with echocardiographic MVP diagnosis in only 39.3%.
Conclusions:
- Asymptomatic mitral valve prolapse (MVP) is frequent in children up to 12 years of age.
- Echocardiography is a significantly more reliable diagnostic test for MVP than the presence of an apical systolic murmur.
- No specific morphological left ventricular correlates were identified in children with MVP.
Abstract:
The prevalence of mitral valve prolapse (MVP) appears to be age related, MVP being commoner in children as compared to adults. This suggests that asymptomatic MVP may be most frequent in children who are very young. In this study, to better define the prevalence of MVP in young children, we used two dimensional echocardiography and prospectively surveyed 213 healthy urban school children between 3 and 12 years of age. MVP was diagnosed when prolapse of mitral leaflet/s was demonstrated by both two-dimensional and M-mode echocardiography at parasternal long-axis views. Overall, MVP was found in 28 of 213 (13.1%) children. MVP was similarly prevalent in all age groups studied (3-5.9 years: 13 of 83 (13.5%); 6-8.9 years: 9 of 71 (11.2%); and 9-12 years: 6 of 31 (16.2%) children; Chi square = 0.57, p greater than 0.5). Univariate analysis showed that the prevalence of MVP was independent of sex, birth weight, resting heart rate and systolic or diastolic blood pressure. A mid systolic murmur was present in 50.6% of the children although it correlated with echocardiographic diagnosis of MVP in only 39.3%. The left ventricular size or wall thickness and mitral EF and DE slopes were similar in children either with or without MVP. Our results indicate that asymptomatic MVP is frequent in children upto 12 years of age. As a diagnostic test of MVP, presence of apical systolic murmur is considerably inferior to echocardiography. No morphological left ventricular correlates were identified in MVP.
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