Related Experiment Video
Updated: Aug 12, 2026
11:56
Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
Managing a mouse mutant resource center...this is not your father's transgenic core
Lisa J Garrett-Beal1, Shelley L Hoogstraten
1Embryonic Stem Cell and Transgenic Core Facility, National Human Genome Research Institute/NIH, Room 4A52, Building 49, 49 Convent Drive, Bethesda, MD 20892-4472, USA. lgarrett@nhgri.nih.gov
Lab Animal
|September 11, 2003
Abstract:
Genetically engineered mice are making an increasingly valuable contribution to biomedical research, and many institutions have begun to assemble dedicated facilities for the development of transgenic animals. The authors describe the structure, function, and management of the transgenic core at NHGRI.
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00:53Transgenic Organisms
Overview
01:16In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...