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Factors affecting survival in maxillary sinus cancer
1Diovision of Otolaryngology, Brigham and Women's Hospital, 333 Longwood Avenue, Boston, MA 02215, USA. neiloy@massmed.org
Summary
Survival for maxillary sinus cancer patients depends on TNM stage, tumor grade, and histology. Radiation therapy improves survival for advanced T4 lesions, while adenoid cystic carcinoma shows better outcomes.
Area of Science:
- Oncology
- Head and Neck Surgery
- Cancer Epidemiology
Background:
- Maxillary sinus malignancies are rare but aggressive tumors.
- Understanding prognostic factors is crucial for effective treatment planning.
Purpose of the Study:
- To identify survival parameters for maxillary sinus malignancies.
- To determine clinical factors influencing survival in these patients.
Main Methods:
- Retrospective analysis of 650 maxillary sinus cancer cases (1988-1998) from the Surveillance, Epidemiology and End Results database.
- Exclusion of cases with distant metastatic disease at presentation.
- Kaplan-Meier and Cox proportional hazards analyses to assess the impact of histology, grade, stage, surgery, and radiation on overall survival.
Main Results:
- Squamous cell carcinoma (61.7%) and adenoid cystic carcinoma (9.8%) were the most common histologies.
- Advanced T stage (T3/T4) and cervical metastasis were present in 77.5% and 7.4% of patients, respectively.
- Radiation therapy improved survival, particularly for T4 lesions. Increasing age, T stage, N stage, and tumor grade predicted poorer survival, while adenoid cystic carcinoma showed significantly better survival.
Conclusions:
- TNM staging, tumor histology, and grade are key determinants of survival for maxillary sinus cancer.
- TNM staging effectively stratifies patients based on prognosis.
- Radiation therapy offers a survival benefit for patients with T4 maxillary sinus lesions.