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[New treatments for heart failure?]
1Clínica de Insuficiencia Cardíaca, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 México, D.F.
Archivos De Cardiologia De Mexico
|September 12, 2003
Abstract:
Treatment of chronic heart failure still needs to be improved. Blockade of ET-1 and TNF-alpha, as well as the combined inhibition of ACE and NE have demonstrated limited benefits, thus other strategies continue being evaluated. This article reviews current concepts regarding the blockade of arginine vasopressin receptors (AVP) and the selective inhibition of matrix metalloproteinases (MMPs). Results with AVP blockade in humans have been encouraging, whereas inhibitors of MMPs continue under preclinical experimental phases and are controversial.