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Controlled release of epidermal growth factor (EGF) from EGF-loaded polymeric nanoparticles composed of polystyrene

In-Kyu Park1, Seog-Jin Seo, Mitsuru Akashi

  • 1School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea.

Archives of Pharmacal Research
|September 12, 2003
PubMed

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...