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Solid-phase synthesis of disulfide heterodimers of peptides
Amit K Galande1, Arno F Spatola
1Department of Chemistry and the Institute for the Molecular Diversity and Drug Design, University of Louisville, Louisville, Kentucky 40292, USA. amitgalande@yahoo.com
Organic Letters
|September 12, 2003
Abstract:
[structure: see text] The synthesis of the orthogonal disulfide template 1 and its use to synthesize unsymmetrical intermolecular disulfide bond peptides on a solid support are described. Application of template 1 to synthesize bioconjugates of cell permeable moieties based on the disulfide bond is demonstrated.