Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroid-insensitive asthma: molecular mechanisms.

I M Adcock1, S J Lane

  • 1Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK. ian.adcock@imperial.ac.uk

The Journal of Endocrinology
|September 12, 2003
PubMed
Summary

Corticosteroid resistance affects a small percentage of asthma patients but incurs significant costs. Understanding corticosteroid insensitivity mechanisms could reveal how these drugs work and lead to new treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correspondence: The First Biosimilar for Biologics in Allergy: CT-P39 (Omlyclo-Omalizumab-Igec) Is Available for Asthma, Chronic Spontaneous Urticaria, and Chronic Rhinosinusitis With Nasal Polyps.

Allergy·2026
Same author

Photoperiod, but not testosterone, increases basal metabolic rate in house sparrows.

Integrative organismal biology (Oxford, England)·2026
Same author

Update on Non-Biological and RNA-Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper.

Allergy·2026
Same author

The Unmet Need of Olfactory Testing in Inflammatory Disorders of the Upper Airways-An EAACI Position Paper.

Allergy·2026
Same author

Reply to Correspondence: The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.

Allergy·2025
Same author

The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.

Allergy·2024

Area of Science:

  • Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Corticosteroids are primary anti-inflammatory treatments for chronic conditions like bronchial asthma.
  • A subset of asthma patients (<5%) exhibit resistance or dependence on corticosteroids, posing therapeutic challenges.
  • This corticosteroid insensitivity is also observed in other inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.

Purpose of the Study:

  • To investigate the underlying mechanisms of corticosteroid insensitivity in asthma.
  • To gain insights into the fundamental actions of corticosteroids.
  • To identify potential therapeutic strategies for corticosteroid-resistant inflammatory diseases.

Main Methods:

  • The abstract does not specify the methods used.

Related Experiment Videos

  • Further research is needed to elucidate the specific methodologies.

    • Main Results:

    • The abstract does not specify the results.
    • Further research is needed to present the findings.

    Conclusions:

    • Understanding corticosteroid insensitivity in asthma may offer broader implications for treating other inflammatory conditions.
    • Identifying the causes of corticosteroid resistance is crucial for developing alternative therapies for severe, non-responsive cases.