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NmcA carbapenem-hydrolyzing enzyme in Enterobacter cloacae in North America
Sudha Pottumarthy1, Ellen Smith Moland, Stefan Juretschko
1University of Washington School of Medicine, Seattle, Washington, USA.
Emerging Infectious Diseases
|September 12, 2003
Abstract:
An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.