[The influence of the dietary polyunsaturated fatty acids on the phagocyte's functional activity in rats]

The influence of dietary polyunsaturated fatty acids on the superoxid anion production by peritoneal macrophages and phagocytosis by blood neutrophiles in male Wistar rats weighting 127.0 +/- 3.2 r was investigated after 3 months feeding. Rats fed isocaloric purified diets contained 24% fat representing combinations of lard, sunflower oil and fish oil (eiconol) providing the ratios of w6/w3 fatty acids equal 49.0; 6.1; 1.1. The increasing of superoxide formed by peritoneal macrophages and phagocytic activity of neutrophiles in the group received diet with the minimal ratios of w6/w3 fatty acids compared to that in rats fed diet with ratio 49.0 was noted. The increased activity of mononuclear-phagocytic system was confirmed by morphological investigation of peripheral lymphoid organs.