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A convergent approach to huperzine A and analogues
Seán A Kelly1, Yann Foricher, John Mann
1School of Chemistry, Queen's University Belfast, Stranmillis Road, Belfast BT9 5AG, Northern Ireland.
Organic & Biomolecular Chemistry
|September 13, 2003
Abstract:
We describe a concise and convergent synthesis of (rac)-5-methoxy-6-azatricyclco[7.3.1.0(2,7)]trideca-2(7),3,5,11-tetraen-13-ol, which has the basic ring system of huperzine A, a potent inhibitor of acetylcholinesterase. We also describe the synthesis of the novel system 5-methoxy-6-azatricyclo[7.2.2.0(2,7)]trideca-2(7),3,5-trien-10-one and a series of related systems.