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[Variations in the purine metabolism of the reperfused heart]
R Zucchi1, G Yu, S Ronca-Testoni
1Istituto di Cardiologia, Università degli Studi, Pisa.
Cardiologia (Rome, Italy)
|October 1, 1992
Abstract:
Isolated hearts were subjected to 30 min of aerobic perfusion followed by 10 min of global normothermic ischemia and 40 min of reperfusion. We determined the release of purine catabolites (adenosine, inosine, hypoxanthine, xanthine, uric acid) and the incorporation of exogenous 3H-adenosine and 14C-hypoxanthine into cellular nucleotides. Ischemia-reperfusion produced remarkable reduction in the release of purine catabolites, with no significant variation in the incorporation of adenosine and hypoxanthine.