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Paranoid psychosis related to mefloquine antimalarial prophylaxis
S J Fuller1, S Naraqi, G Gilessi
1Sydney University Department of Medicine, Nepean Hospital, Australia.
Abstract:
Mefloquine is an important antimalarial drug for treatment and prophylaxis of chloroquine-resistant malaria. Its use has been associated with neuropsychiatric side-effects. We report a case of paranoid psychosis associated with mefloquine occurring in a remote part of Papua New Guinea. Adverse reactions and contraindications are discussed. This case underlines the importance of awareness of neuropsychiatric side-effects with mefloquine use and of taking a careful psychiatric history before prescribing mefloquine.
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