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Updated: Aug 3, 2026
Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
Toshio Sakaki1, Isao Tamura, Hidetaka Kadota
1Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Osaka, Japan. sakaki-t@cc.osaka-dent.ac.jp
Background:
Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated.
Methods:
The expression of E-CD and P-CD was examined immunohistochemically and biochemically in a 4-nitroquinoline 1-oxide (4NQO)-induced rat model of carcinogenesis.
Results:
The expression of E-CD in the pre-malignant stage was the same as that in the normal epithelium. The expression of P-CD was even throughout the prickle cell layer in the dysplasia stage. E-CD and P-CD were expressed in essentially the same locations in SCC and in the pre-malignant stage. P-CD expression was very strong in the pre-malignant stage, compared to that in normal epithelium.
Conclusions:
Aberrant P-CD expression in E-CD-positive cells may play a crucial role in the progression of the pre-malignant stage of 4NQO-induced carcinogenesis, and may activate mechanisms responsible for cell proliferation.
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