Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphoid organ development and cell migration.

Jason G Cyster1

  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143-0414, USA. cyster@itsa.ucsf.edu

Immunological Reviews
|September 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal intraepithelial lymphocyte migration and tissue homeostasis are dictated by Gα13.

bioRxiv : the preprint server for biology·2026
Same author

ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine.

The Journal of experimental medicine·2025
Same author

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors.

bioRxiv : the preprint server for biology·2025
Same author

Author Correction: EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells.

Nature·2025
Same author

Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8.

Cell genomics·2025
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

Understanding lymphoid organ function is crucial for developing new drugs to control immune responses. This research explores key regulators and cellular dynamics in thymus and secondary lymphoid organs for improved human health.

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • The increasing prevalence of infectious diseases, bioweapon threats, advancements in transplantation, and gene therapy necessitate enhanced immune modulation strategies.
  • A novel immunosuppressant targeting lymphocyte egress from lymphoid organs highlights the importance of understanding lymphoid organ function for drug development.

Purpose of the Study:

  • To consolidate current knowledge on thymus and secondary lymphoid organ biology.
  • To explore the molecular and cellular mechanisms governing immune function and its modulation.

Main Methods:

  • Review of key transcriptional regulators (e.g., Foxn1, retinoid-related orphan receptor gamma, nuclear factor-kappaB) in lymphoid organ development.
  • Analysis of cytokine (e.g., lymphotoxin) and chemokine roles in lymphoid tissue organization and immune cell positioning.

Related Experiment Videos

  • Investigation of the immunosuppressant FTY720's mechanism of action.
  • Application of advanced imaging techniques like two-photon laser scanning microscopy to visualize cellular dynamics.

    • Main Results:

    • Detailed insights into the roles of specific transcriptional regulators in lymphoid organogenesis.
    • Elucidation of cytokine and chemokine signaling pathways critical for immune tissue architecture and cell trafficking.
    • Understanding the mechanism by which FTY720 suppresses immune responses by blocking lymphocyte exit.
    • Dynamic visualization of immune cell behavior within lymphoid organs.

    Conclusions:

    • Advances in understanding lymphoid organ biology are pivotal for developing novel immunomodulatory therapies.
    • Targeting lymphocyte trafficking and organ development offers promising avenues for treating immune-related diseases and threats.
    • Integrated approaches combining molecular, cellular, and imaging techniques are essential for future progress in immunology.