Related Experiment Video
Updated: Aug 26, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Protective effects of glycyrrhizin on gentamicin-induced acute renal failure in rats
Eun-Jin Sohn1, Dae-Gill Kang, Ho-Sub Lee
1Professional Graduate School of Oriental Medicine and Medicinal Resources Research Center, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
Abstract:
The aim of this study was to investigate the effects of glycyrrhizin (200 mg/kg/day) on renal function in association with the regulation of aquaporin 2 water channel in rats with gentamicin (100 mg/kg/day)-induced acute renal failure. Polyuria in rats with gentamicin-induced acute renal failure was associated with down-regulation of renal aquaporin 2 in the inner and outer renal medulla, and cortex. Glycyrrhizin administration restored the expression of aquaporin 2 with paralleled changes in urine output. Changes in renal functional parameters, such as creatinine clearance, urinary osmolality, and solute-free reabsorption, accompanying acute renal failure were also partially restored after administration of glycyrrhizin. Histological changes in rats with gentamicin-induced acute renal failure were also abrogated by glycyrrhizin treatment. The above results suggest that glycyrrhizin treatment could ameliorate renal defects in rats with acute renal failure induced by gentamicin.
Related Concept Videos
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Acute Kidney Injury IV: Diagnostic Studies and Prevention

