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Genetic amniocentesis: a risk factor for preterm delivery?

Emanuela Medda1, Serena Donati, Angela Spinelli

  • 1Department of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. emedda@iss.it

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 13, 2003
PubMed
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Second trimester genetic amniocentesis is linked to an increased risk of preterm delivery. This finding highlights the need for further research into the causal role of this common prenatal diagnostic procedure.

Area of Science:

  • Obstetrics and Gynecology
  • Prenatal Diagnostics
  • Perinatology

Background:

  • Genetic amniocentesis is a widely used prenatal diagnostic technique.
  • Preterm delivery remains a significant concern in maternal and infant health.

Purpose of the Study:

  • To investigate the association between second-trimester genetic amniocentesis and the risk of preterm delivery.

Main Methods:

  • A European case-control study involving 3,091 preterm births and 5,298 term-born controls.
  • Logistic regression models were employed to analyze the association, adjusting for confounding variables.

Main Results:

  • Second-trimester genetic amniocentesis was associated with an increased risk of preterm delivery (OR=1.59, 95% CI: 1.31-1.92).

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  • This association was significant for both spontaneous and induced preterm deliveries.

    • Conclusions:

    • Genetic amniocentesis performed in the second trimester shows an association with preterm delivery.
    • Further research is warranted to elucidate the etiological role of genetic amniocentesis in preterm birth.