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Feto-maternal alloimmune thrombocytopenia due to HPA-5b incompatibility: a case report
Rafael J M Herrero1, Yvon Chitrit, Patrick Caubel
1Department of Obstetrics and Gynaecology, Hôpital Robert Ballanger, Aulnay-Sous-Bois, Paris, France. rherrero@club-internet.fr
Abstract:
Feto-maternal alloimmune thrombocytopenia (FMAIT) results from the maternal production of antibodies against fetal platelets with incompatible antigens inherited from the father. We present a case where this condition was diagnosed prenatally without previously affected siblings. The severe fetal thrombocytopenia was due to anti-HLA-5b maternal alloantibodies. This was treated successfully by intravenous immunoglobulins. Our case reflects that FMAIT due to anti-HPA-5b may be severe and may be corrected successfully with intravenous immunoglogulins.
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