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Antibody level after measles vaccination.
M M Fathy1, T H el-Khashaab, M A Darwish
1Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
The Journal of the Egyptian Public Health Association
|January 1, 1992
Summary
This study assessed measles IgG antibody levels in infants and preschool children to evaluate immune status post-vaccination. While vaccination increased antibody levels, some infants and children showed insufficient immunity, indicating potential vaccination failure.
Area of Science:
- Immunology
- Pediatrics
- Vaccinology
Background:
- Assessing vaccine effectiveness is crucial for public health.
- Measles IgG antibody levels indicate protective immunity.
- Infant and preschooler immune status requires regular monitoring.
Purpose of the Study:
- To estimate measles IgG antibody levels in infants post-vaccination and in preschool children.
- To determine the immune status of these populations.
- To identify potential vaccination failures.
Main Methods:
- Study included three groups: unvaccinated infants, recently vaccinated infants, and vaccinated preschool children.
- Measles IgG antibody levels were measured using the ELISA technique.
- Statistical analysis compared antibody levels across groups.
Main Results:
- Unvaccinated infants primarily had maternal antibodies.
- 50% of recently vaccinated infants were seropositive, with a significant increase compared to unvaccinated infants.
- 77.4% of preschool children were seropositive, with higher antibody levels than vaccinated infants, possibly due to subclinical infections.
- Vaccination failure was suggested in 50% of vaccinated infants and 22.6% of preschool children.
Conclusions:
- Measles vaccination significantly boosts IgG antibody levels in infants.
- A notable percentage of vaccinated children may not achieve protective immunity.
- Further investigation into vaccination strategies and immune response is warranted.