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Factor XII deficiency is strongly associated with primary recurrent abortions
Hans-Ulrich Pauer1, Peter Burfeind, Heinz Köstering
1Department of Gynecology and Obstetrics, University Hospital of Goettingen, Goettingen, Germany. hpauer@gwdg.de
Fertility and Sterility
|September 13, 2003
Summary
Factor XII deficiency is linked to recurrent pregnancy loss. This study found a significant association between low factor XII activity and primary recurrent abortion, with a tendency observed in secondary recurrent abortion cases.
Area of Science:
- Reproductive Medicine
- Hematology
- Genetics
Background:
- Recurrent abortion affects a significant number of women.
- The role of thrombophilia in recurrent abortion is an area of ongoing research.
- Factor XII deficiency is a less commonly investigated potential risk factor.
Purpose of the Study:
- To investigate the prevalence of factor XII deficiency in women experiencing primary and secondary recurrent abortions.
- To determine if factor XII deficiency is associated with unexplained recurrent pregnancy loss.
Main Methods:
- A prospective case-control study was conducted.
- Included were 67 women with primary recurrent abortion, 33 with secondary recurrent abortion, and 49 healthy controls.
- Evaluated parameters included plasma factor XII activity, activated protein C resistance, factor V Leiden mutation, and other thrombophilia markers.
Main Results:
- Reduced factor XII activity (<60%) was observed in 14.9% of women with primary recurrent abortion and 12.1% with secondary recurrent abortion.
- These findings were statistically significant for primary recurrent abortion and showed a trend for secondary recurrent abortion.
- All control subjects exhibited normal factor XII activity.
Conclusions:
- Factor XII deficiency is strongly associated with primary recurrent abortion.
- A tendency towards factor XII deficiency was noted in women with secondary recurrent abortion.
- Further research may clarify the clinical implications of factor XII deficiency in recurrent pregnancy loss.
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