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A potential new use for gonadotropin-releasing hormone antagonists
Thomas R Aust1, John Sklavounos, Charles R Kingsland
1Department of Reproductive Medicine, Liverpool Women's Hospital, Liverpool, United Kingdom. tomaust@doctors.org.uk
Objective:
To describe a potential new use of gonadotropin-releasing hormone (GnRH) antagonists.
Design:
Case report.
Setting:
Assisted conception unit at a teaching hospital in the United Kingdom.
Patient(S):
A 37-year-old woman undergoing in vitro fertilization (IVF) who accidentally stopped using GnRH agonists after starting ovarian stimulation.
Intervention(S):
A GnRH antagonist was used to avoid a luteinizing hormone (LH) surge and hence "rescue" the cycle.
Result(S):
Successful oocyte retrieval was carried out, two embryos transferred, and a viable twin pregnancy ensued.
Conclusion(S):
This may be a new indication for the use of GnRH antagonists.