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Updated: Aug 5, 2026

On-Chip Endothelial Inflammatory Phenotyping
Published on: July 22, 2012
The concentrations of soluble vascular cell adhesion molecule-1 and lipids are independently associated with venous
Angel José González-Ordóñez1, José-Manuel Fernández-Carreira, Carmen Rosa Fernández-Alvarez
1Department of Hematology, Hospital San Agustin, 33400, Avilés, Spain. jagonzalez@medynet.com
Background And Objectives:
Venous thromboembolism (VTE) involves inflammation and a relation with dyslipidemia which remains controversial. The vascular cell adhesion molecule-1 (VCAM-1) is a ligand expressed by activated endothelium (and recruits leukocytes) whose soluble form (sVCAM-1) increases in atherosclerosis, severe hypertriglyceridemia or deep vein thrombosis (DVT) in acute phase. We analyzed the association between VTE (> 6 months after), sVCAM-1 and lipid concentrations.
Design And Methods:
Case-control study involving 126 consecutive patients (aged 25-80 years, 49% males) and 125 controls of similar age and gender.
Results:
The patients had a more unfavorable lipid profile than controls [higher triglycerides (p<0.001), LDLc/HDLc ratio (p<0.01) or total cholesterol (TC) (p=0.07)] and higher sVCAM-1 concentration (p<0.01) even adjusting for arterial diseases. VTE was associated with extreme values of TC, LDL-c, triglycerides (>P90) and HDL-c (
Interpretation And Conclusions:
Although the exact mechanisms linking abnormal lipid and sVCAM-1 concentrations to VTE await clarification, both seem to be independently associated.
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