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Related Experiment Videos

Soy phytoestrogens do not prevent bone loss in postmenopausal monkeys.

Thomas C Register1, Manuel J Jayo, Mary S Anthony

  • 1Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27103-1040, USA. register@wfubmc.edu

The Journal of Clinical Endocrinology and Metabolism
|September 13, 2003
PubMed
Summary

Dietary soy phytoestrogens (SPE) did not protect ovariectomized monkeys from bone loss, unlike conjugated equine estrogens (CEE). SPE showed no significant bone mass effects, suggesting they are poor substitutes for estrogen in preventing bone loss.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Nutritional Science

Background:

  • Estrogen deficiency following ovariectomy leads to significant bone loss.
  • Dietary soy phytoestrogens (SPE) are plant-derived compounds with potential estrogenic activity.
  • Conjugated equine estrogens (CEE) are a known therapy for mitigating bone loss.

Purpose of the Study:

  • To compare the skeletal effects of dietary soy phytoestrogens (SPE) with conjugated equine estrogens (CEE) in ovariectomized female monkeys.
  • To evaluate the efficacy of SPE in preventing bone loss associated with estrogen deficiency.

Main Methods:

  • A 3-year longitudinal study involving ovariectomized female monkeys.
  • Groups received either CEE, soy protein isolate with SPE, or a control diet.

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  • Bone mass was assessed using dual energy x-ray absorptiometry (DXA).
  • Bone turnover markers were monitored in serum.

    • Main Results:

    • CEE treatment resulted in higher bone mass and lower bone turnover markers.
    • Both control and SPE groups experienced significant bone mineral density loss in the lumbar spine and whole body within the first year.
    • SPE did not demonstrate any significant effect on bone mass measures (P > 0.44).
    • Transient, estrogen-like effects of SPE were observed on serum alkaline phosphatase, calcium, and C-terminal cross-link of type I collagen at 3 months (P < 0.02).

    Conclusions:

    • Dietary soy phytoestrogens (SPE) are ineffective in preventing bone loss in ovariectomized monkeys.
    • SPE are poor substitutes for mammalian estrogens like CEE in protecting against bone loss due to estrogen deficiency.