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[Candida krusei in genital infections].

B Pawlik1, B Bogusz

  • 1Zakład Mykologii Instytutu Mikrobiologii AM, Krakowie.

Medycyna Doswiadczalna I Mikrobiologia
|January 1, 1992
PubMed
Summary

Candida krusei is a significant cause of vaginal mycosis, often occurring with normal vaginal conditions but altered leukocytosis. Cotrimazine and pimaricin show the highest activity against these fungi.

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Area of Science:

  • Medical Mycology
  • Clinical Microbiology
  • Infectious Diseases

Background:

  • Candida krusei is an opportunistic fungal pathogen.
  • It is a common cause of yeast-like fungal infections in the human reproductive tract.
  • Understanding its prevalence and drug susceptibility is crucial for effective treatment.

Purpose of the Study:

  • To investigate the frequency of Candida krusei in the human reproductive tract.
  • To determine the susceptibility of Candida krusei strains to various antifungal drugs.
  • To assess the role of Candida krusei in the pathogenesis of vaginal mycosis.

Main Methods:

  • Microbiological culture and identification of yeast strains from patient samples.
  • Antifungal susceptibility testing (drug sensitivity assays).
  • Clinical data collection on patient symptoms and vaginal environment parameters (pH, leukocytosis).

Main Results:

  • Candida krusei accounted for 6.7% of all yeast strains and 21.8% of non-albicans Candida species.
  • Infections often occurred with normal vaginal Lactobacillus sp. presence and pH, but elevated leukocytosis.
  • Over 60% of infected patients reported reproductive tract disturbances.
  • Cotrimazine and pimaricin demonstrated the highest in vitro activity against Candida krusei.

Conclusions:

  • Candida krusei is a relevant pathogen in vaginal mycosis, even in seemingly favorable host conditions.
  • The study highlights significant patient-reported symptoms associated with Candida krusei infections.
  • Cotrimazine and pimaricin are promising therapeutic agents for Candida krusei infections.

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