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[Candida krusei in genital infections]
Abstract:
Frequency of appearance of Candida krusei in human reproductive tract, susceptibility of these microorganisms to drugs and their importance in pathogenesis of mycosis, were investigated. Strains C. krusei species constituted 6.7% of the total 1325 strains and 21.8% within other than C. albicans species yeast-like fungi. Vaginal mycosis caused by fungi from C. krusei species occurs in presence of Lactobacillus sp. and correct values of pH in vaginal contents, however changed leukocytosis in evident. Over 60% of patients with C. krusei infection were complaining that they feel disturbances within the reproductive tract. Investigation of susceptibility of C. krusei to drugs revealed highest activity of cotrimazine and pimaricin.
Insights
Candida krusei is a significant cause of vaginal mycosis, often occurring with normal vaginal conditions but altered leukocytosis. Cotrimazine and pimaricin show the highest activity against these fungi.
Area of Science:
- Medical Mycology
- Clinical Microbiology
- Infectious Diseases
Background:
- Candida krusei is an opportunistic fungal pathogen.
- It is a common cause of yeast-like fungal infections in the human reproductive tract.
- Understanding its prevalence and drug susceptibility is crucial for effective treatment.
Purpose of the Study:
- To investigate the frequency of Candida krusei in the human reproductive tract.
- To determine the susceptibility of Candida krusei strains to various antifungal drugs.
- To assess the role of Candida krusei in the pathogenesis of vaginal mycosis.
Main Methods:
- Microbiological culture and identification of yeast strains from patient samples.
- Antifungal susceptibility testing (drug sensitivity assays).
- Clinical data collection on patient symptoms and vaginal environment parameters (pH, leukocytosis).
Main Results:
- Candida krusei accounted for 6.7% of all yeast strains and 21.8% of non-albicans Candida species.
- Infections often occurred with normal vaginal Lactobacillus sp. presence and pH, but elevated leukocytosis.
- Over 60% of infected patients reported reproductive tract disturbances.
- Cotrimazine and pimaricin demonstrated the highest in vitro activity against Candida krusei.
Conclusions:
- Candida krusei is a relevant pathogen in vaginal mycosis, even in seemingly favorable host conditions.
- The study highlights significant patient-reported symptoms associated with Candida krusei infections.
- Cotrimazine and pimaricin are promising therapeutic agents for Candida krusei infections.