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Recombination in circulating enteroviruses.

Alexander N Lukashev¹, Vasilii A Lashkevich, Olga E Ivanova

¹Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia. alexander_lukashev@hotmail.com

Journal of Virology

|September 13, 2003

Summary

Most circulating enterovirus B strains are recombinants, not matching their original types. This ubiquitous recombination allows independent evolution of enterovirus genome regions, suggesting a novel genetic model.

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Area of Science:

Virology
Molecular Biology
Genetics

Background:

Recombination is known in enteroviruses, but its extent in nonpolio strains is unclear.
Enterovirus B strains (coxsackie B and echoviruses) are significant human pathogens.

Purpose of the Study:

To investigate the extent of recombination in circulating enterovirus B strains.
To analyze phylogenetic relationships across different genomic regions of enterovirus B.

Main Methods:

Phylogenetic analysis of four genome regions (VP1, 2A, 3D, 5' NTR) from 40 enterovirus B strains.
Comparison of viral strains isolated between 1981-2002 in former Soviet Union states with prototype strains.

Main Results:

Phylogenetic grouping varied significantly across genome regions, indicating recombination.

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Most strains showed recombination in the 2A, 5' NTR, and 3D regions, differing from VP1 groupings.

A major group united most strains in the 5' NTR and 3D regions, irrespective of serotype.

Conclusions:

A majority of circulating enterovirus B strains are recombinants relative to older prototype strains.
Ubiquitous recombination enables independent evolution of enterovirus genome segments.
A new model proposes enterovirus genomes as stable gene symbioses with evolving nonstructural genes.