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Ultrasound contrast imaging research
Michalakis Averkiou1, Jeff Powers, Dan Skyba
1Philips Medical Systems/Philips Ultrasound, Bothell, Washington 98041-3003, USA. mike.averkiou@philips.com
Ultrasound Quarterly
|September 13, 2003
Summary
This review covers ultrasound contrast agents for general imaging, detailing microbubble properties and advanced imaging techniques. It explores their clinical use, approved in Europe but pending FDA approval in the US.
Area of Science:
- Medical Imaging
- Diagnostic Ultrasound
- Contrast-Enhanced Ultrasound
Background:
- Ultrasound contrast agents are under investigation for general imaging in the US, though approved in Europe.
- Microbubble properties, including nonlinear behavior and destruction, are key to their function.
- General imaging applications are still awaiting FDA approval.
Purpose of the Study:
- To review current research on ultrasound contrast agents in general imaging.
- To explain the properties of contrast microbubbles and relevant imaging techniques.
- To demonstrate the utility of these agents in visualizing liver tumors.
Main Methods:
- Review of existing research literature on ultrasound contrast agents.
- Explanation of microbubble characteristics (nonlinear behavior, destruction).
- Description of advanced ultrasound imaging modalities (harmonic, pulse inversion, agent detection, etc.).
Main Results:
- Ultrasound contrast agents exhibit nonlinear behavior and specific destruction properties.
- Various advanced imaging techniques enhance contrast agent visualization.
- Different liver tumors show distinct blood flow patterns with contrast agents.
Conclusions:
- Ultrasound contrast agents offer valuable insights into tissue perfusion and tumor vascularity.
- Advanced imaging techniques are crucial for optimizing the diagnostic performance of contrast agents.
- Further research and regulatory approval are needed for widespread US adoption.