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Related Experiment Videos

[Phenprocoumon-induced liver failure].

A Cordes1, W Vogt, H H Dahm

  • 1Medizinische Klinik, Fachbereich Gastroenterologie, Städtische Kliniken Esslingen/N., Akademisches Lekrankenhaus der Universität Tübingen, Esslingen.

Deutsche Medizinische Wochenschrift (1946)
|September 13, 2003
PubMed
Summary
This summary is machine-generated.

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Drug-induced liver injury from phenprocoumon can occur after prolonged use. A thorough medication history is crucial for diagnosing hepatitis of unknown cause.

Area of Science:

  • Hepatology
  • Pharmacology
  • Internal Medicine

Background:

  • Drug-induced liver injury (DILI) is a significant cause of acute liver dysfunction.
  • Phenprocoumon, an anticoagulant, is widely prescribed for conditions like atrial fibrillation.
  • Identifying the causative agent is critical for effective management of DILI.

Observation:

  • A 61-year-old woman presented with painless jaundice and impaired liver function tests.
  • Despite two years of phenprocoumon therapy for atrial fibrillation, she developed hepatitis.
  • Liver biopsy revealed hepatocellular necrosis and mild inflammation, consistent with drug-induced hepatic disease.

Findings:

  • Serological tests ruled out infectious, autoimmune, and metabolic causes of hepatitis.

Related Experiment Videos

  • Surgical intervention for a duodenal ulcer preceded further liver function deterioration.
  • Discontinuation of phenprocoumon and symptomatic treatment led to slow but steady improvement.

    • Implications:

    • Phenprocoumon can induce liver damage even after extended asymptomatic use.
    • A comprehensive drug history is essential for diagnosing hepatitis of uncertain etiology.
    • This case highlights the importance of considering iatrogenic causes in liver disease.