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Updated: Sep 20, 2026
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
[Surgical treatment of giant cell tumor of bone]
Michael Davidsen1, Johnny Ø Keller, Peter Holmberg Jørgensen
1Arhus Universitetshospital, Arhus Kommunehospital, Ortopaedkirurgisk Afdeling E, Onkologisk Afdeling D og Radiologisk afdeling R.
Introduction:
This study analyses a 5-year follow-up after treatment of giant cell tumour of bone during a 31-year period.
Material And Methods:
Sixty patients with giant cell tumours of bone had been treated at the Centre for Musculoskeletal Tumours at Aarhus University Hospital. All patients were followed at regular intervals for 5-35 years, median = 11 years.
Results:
There were 54 benign giant cell tumours of bone, whereas six were classified as malignant. The most common location was around the knee. There were nine cases of recurrence. The 5-year recurrence-free survival was 77%. The lowest frequency of recurrence appeared after resection (6%) and the highest after bone-transplantation (22%).
Discussion:
The classical microscopic and macroscopic criteria for malignancy are not applicable for this rare tumour. All giant cell tumours of bone should be considered as potentially malignant, and therefore patients should be referred to a Centre for Musculoskeletal Tumours.
