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Related Experiment Videos

Prophylaxis latency and outcome in bipolar disorders.

Christopher Baethge1, Leonardo Tondo, Irene M Bratti

  • 1Consolidated Department of Psychiatry, Harvard Medical School, Bipolar and Psychotic Disorders Program, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts, USA. cbaethge@mclean.harvard.edu

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|September 16, 2003
PubMed
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Delayed mood-stabilizer treatment for bipolar disorder (BD) does not appear to limit treatment response. Early treatment may seem beneficial but this effect disappears when accounting for illness severity before treatment begins.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Bipolar disorder (BD) is a chronic mental health condition.
  • Mood-stabilizer prophylaxis is a key treatment for BD.
  • The impact of treatment delay on BD outcomes is debated.

Purpose of the Study:

  • To evaluate the relationship between the time from bipolar disorder onset to mood-stabilizer prophylaxis and treatment response.
  • To analyze new and existing research on treatment latency in BD.

Main Methods:

  • Meta-analysis of 11 studies involving 1485 adult patients with BD.
  • Analysis of new data combined with findings from computerized literature searches.

Main Results:

  • Average latency to prophylaxis was 9.6 years.

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  • Shorter treatment latency was associated with greater illness intensity.
  • Apparent treatment benefits were not sustained after correcting for pretreatment illness severity.
  • Treatment latency did not predict morbidity during treatment.

    • Conclusions:

    • Current evidence does not support the idea that delayed prophylaxis negatively impacts treatment response in bipolar disorder.
    • Misleading conclusions about treatment effectiveness can arise from uncorrected data.