Pharmacokinetics of amikacin in gamma-irradiated mice

Concentrations of amikacin in sera, investigated 24 h after irradiation with 9 Gy gamma-rays of mice, were monitored using TDX system (Abbott), based on the fluorescence polarization immunoassay. Pharmacokinetic parameters of disposition (distribution + elimination) of the drug were calculated from the obtained data. In irradiated mice fast and slow phases of amikacin disposition were noted. In contrary, in the non irradiated mice only one-fast phase of the drug disposition was observed. The dependence of the disposition parameters of the antibiotic to the postirradiation tubular dystrophia and vascular changes was discussed.