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Trimethylamine and odorous sweat.

S C Mitchell1, R L Smith

  • 1Section of Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, UK.

Journal of Inherited Metabolic Disease
|September 16, 2003
PubMed
Summary
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Trimethylamine is the primary cause of ichthyohidriosis, a condition causing fishy body odor. This finding comes from analyzing sweat from patients and volunteers with induced odor phenomena.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Odorant Analysis

Background:

  • Ichthyohidriosis, characterized by a fish-like body odor, presents a diagnostic and social challenge.
  • The specific volatile compounds responsible for this malodor have not been definitively identified.

Purpose of the Study:

  • To identify the causative agent responsible for the characteristic odor in ichthyohidriosis.
  • To confirm the role of identified compounds in artificially induced odor phenomena.

Main Methods:

  • Sweat samples were collected from patients diagnosed with ichthyohidriosis.
  • Sweat samples were also obtained from healthy volunteers after artificial induction of the odor phenomenon.
  • Gas chromatography-mass spectrometry was employed for chemical analysis of sweat volatiles.

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Main Results:

  • Trimethylamine was identified as the predominant volatile compound in the sweat of ichthyohidriosis patients.
  • Artificial induction of the odor phenomenon in volunteers also resulted in elevated levels of trimethylamine in sweat.

Conclusions:

  • Trimethylamine is the major causative factor responsible for the malodor associated with ichthyohidriosis.
  • This finding provides a biochemical basis for understanding and potentially managing this condition.