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Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Updated: Jul 12, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

Kidney transplantation at UCLA.

H Albin Gritsch1, Craig V Smith, Jacob Rajfer

  • 1UCLA Kidney and Pancreas Transplant Program, Center for the Health Sciences, Los Angeles, California, USA.

Clinical Transplants
|September 16, 2003
PubMed
Summary
This summary is machine-generated.

Living kidney donation offers excellent results, with improved techniques reducing donor risk. This approach is vital as demand for kidney transplants rises, with living donor kidneys showing high graft survival rates.

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Area of Science:

  • Nephrology
  • Transplant Surgery
  • Immunology

Background:

  • Increasing demand for renal transplantation globally.
  • Living kidney donation is a growing source of organs, accounting for 35% of transplants at UCLA.
  • Advancements in surgical techniques and postoperative care have reduced donor morbidity.

Purpose of the Study:

  • To evaluate the outcomes of renal transplantation at UCLA, focusing on living donor versus cadaveric donor kidneys.
  • To assess graft survival rates and the impact of medical advancements on transplant success.
  • To highlight the program's adaptation to the evolving landscape of organ transplantation.

Main Methods:

  • Retrospective analysis of 1,307 renal transplants performed at UCLA over 5 years.
  • Comparison of graft survival rates between living donor and cadaveric donor kidney recipients (adults and pediatric).
  • Review of advancements in immunosuppressive, antibiotic, and antiviral medications.

Main Results:

  • One- and 3-year graft survival rates for living donor kidneys were 98% and 90% (adults), and 100% and 97% (pediatric).
  • One- and 3-year graft survival rates for cadaveric grafts were 91% and 82% (adults), and 97% and 85% (pediatric).
  • Significant reductions in acute rejection and infections due to improved medications.

Conclusions:

  • Living donor kidney transplantation yields excellent graft survival rates, comparable or superior to cadaveric grafts.
  • Improvements in medical and surgical management have enhanced transplant outcomes and patient safety.
  • The UCLA transplant program demonstrates successful adaptation to increasing demand and evolving transplant practices.