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Beta A4 amyloid protein and its precursor in Alzheimer's disease
A I Bush1, K Beyreuther, C L Masters
1Department of Pathology, University of Melbourne, Parkville, Australia.
Pharmacology & Therapeutics
|January 1, 1992
Abstract:
The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.