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Updated: Aug 13, 2026
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Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
Published on: August 13, 2010
Pathologic study of acute toxoplasmosis in experimental animals
Yaowalark Sukthana1, Phuangphet Waree, Emsri Pongponratn
1Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. tmymv@mahidol.ac.th
The Southeast Asian Journal of Tropical Medicine and Public Health
|September 16, 2003
Summary
Acute toxoplasmosis in mice infected with Toxoplasma gondii tachyzoites caused fatal disseminated disease. This mouse model effectively mimics severe Toxoplasma reactivation in immunocompromised individuals.
Area of Science:
- Immunology
- Infectious Diseases
- Pathology
Background:
- Toxoplasma gondii is an opportunistic parasite causing severe disease in immunocompromised hosts.
- Understanding the pathology of acute toxoplasmosis is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the pathological features of acute toxoplasmosis in a murine model.
- To evaluate the suitability of this model for studying Toxoplasma reactivation in immunosuppressed individuals.
Main Methods:
- Experimental infection of mice with RH strain tachyzoites of Toxoplasma gondii.
- Histopathological examination of liver, spleen, and pancreas.
Main Results:
- All inoculated mice succumbed to severe, disseminated toxoplasmosis.
- Significant pathological changes were observed in the liver, spleen, and pancreas.
Conclusions:
- Acute toxoplasmosis in this mouse model results in fatal disseminated disease.
- The observed pathology serves as a relevant model for studying Toxoplasma reactivation in immunosuppressed hosts.
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