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Prevalence of antidepressant-associated erectile dysfunction
Raymond C Rosen1, Humberto Marin
1Department of Psychiatry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08554-5653, USA. rosen@umdnj.edu
The Journal of Clinical Psychiatry
|September 16, 2003
Summary
Erectile dysfunction is common in depression and can be a side effect of antidepressant medications, affecting up to 90% of men. Addressing this sexual dysfunction is key for treatment adherence.
Area of Science:
- Psychiatry
- Sexual Medicine
- Pharmacology
Background:
- Sexual dysfunction, particularly erectile dysfunction (ED), is prevalent in the general population.
- ED is a common symptom in both untreated and treated depression.
- Antidepressant therapy can cause or exacerbate sexual dysfunction, including ED.
Purpose of the Study:
- To review the prevalence of ED and related sexual dysfunction in untreated depression and secondary to antidepressant medications.
- To compare ED rates in depressed populations with healthy controls.
- To examine the mechanisms of serotonin reuptake inhibitor (SRI)-associated ED and its assessment and management.
Main Methods:
- Literature review of available data on ED prevalence.
- Analysis of studies comparing ED in depressed versus healthy populations.
- Examination of mechanisms and assessment strategies for SRI-associated ED.
Main Results:
- Antidepressant-emergent sexual side effects, including ED, may affect up to 90% of men.
- Detailed patient history is crucial for accurate prevalence assessment.
- SRI-associated ED is a significant and prevalent side effect.
Conclusions:
- ED is a frequent issue in depression and a notable side effect of antidepressant treatment.
- Effective management of antidepressant-associated ED can improve patient adherence to depression treatment.
- Understanding and addressing ED is vital for comprehensive patient care in depression.