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Related Experiment Videos

Factors affecting grip strength testing.

Jacques P J Maurissen1, Brian R Marable, Amanda K Andrus

  • 1Toxicology & Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA. jpjm@dow.com

Neurotoxicology and Teratology
|September 16, 2003
PubMed
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The rodent grip strength test is influenced by factors beyond muscle strength, such as operational parameters, sensory function, and body weight. Reporting exact test conditions is crucial for accurate interpretation of grip performance data.

Area of Science:

  • Neuroscience
  • Toxicology
  • Animal Models

Background:

  • The rodent grip strength test is widely used to assess motor neurotoxicity.
  • Its interpretation as a direct measure of muscular strength is questioned due to potential confounding factors.

Purpose of the Study:

  • To identify and evaluate potential confounders of the rodent grip strength test.
  • To improve the accuracy and consistency of grip strength measurements in toxicological studies.

Main Methods:

  • Investigated the impact of operational parameters (sampling rate, system type, trial angle, trial speed) on grip strength.
  • Assessed sensory impairment using doxorubicin and its correlation with grip strength changes.
  • Evaluated the effects of feed restriction-induced body and muscle mass loss on grip strength.

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Main Results:

  • Operational parameters significantly affected grip strength data, with sampling rate, system type, and trial angle being key factors.
  • Doxorubicin-induced sensory impairment reduced forelimb and hindlimb grip strength, correlating with neural degeneration.
  • Body and muscle mass loss from feed restriction reversibly decreased grip strength in both forelimbs and hindlimbs.

Conclusions:

  • Grip strength measurements are susceptible to confounding variables including operational settings, sensory deficits, and body/muscle mass.
  • The term "grip performance" is proposed to more accurately reflect the test's outcome.
  • Detailed reporting of test conditions is recommended for improved data interpretation and consistency.