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Updated: Sep 20, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Syncope in children and adolescents and the congenital long QT syndrome
Anant Khositseth1, Matthew W Martinez, David J Driscoll
1Department of Pediatric and Adolescent Medicine/Division of Pediatric Cardiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Abstract:
From a population-based epidemiologic cohort of children and adolescents who sought medical attention for syncope (n = 151), screening 12-lead electrocardiograms were obtained from 118 patients (79 female) to determine the frequency of significant QT prolongation. The distribution of heart rate corrected QT intervals (QTc) was compared with age- and sex-matched controls. Only one patient had QTc >470 ms.
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